The Uremic Myocardium and Ischemic Tolerance

The uremic myocardium and ischemic tolerance: a world of difference.

Uremia is associated with an increased prevalence of ischemic heart disease. Already, at the start of dialysis, the prevalence of coronary artery disease is 38%.1 The frequency of myocardial infarction in renal patients is high and the outcome is poor.2 Despite significant improvement of therapeutic modalities, the unadjusted 2-year mortality for dialysis patients after acute myocardial infarct...

Ischemic Tolerance in Uremic Rabbits

Background: Cardiac complications after myocardial infarction are believed to be worse in the presence of comorbidities; we tested whether experimentally induced prolonged uremia exacerbated myocardial necrosis in a rabbit preparation of ischemia-reperfusion injury. In addition, we examined if treatment with an angiotensin converting enzyme inhibitor (Enalapril, ENA, 3 mg/Kg, IV) could reduce p...

The Uremic Myocardium and Ischemic Tolerance : A World of Difference Running title :

Ischemic preconditioning of myocardium.

Preconditioning of the myocardium with short episodes of sublethal ischemia will delay the onset of necrosis during a subsequent lethal ischemic insult. Ischemic preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel...

Acutely Ischemic Myocardium

The effect of intra-aortic balloon counterpulsation (IABC) on the motion and perfusion of ischemic left ventricular posterior myocardium was studied in 30 open-chest dogs, using ultrasound to register motion and 7-10 ,u radioactive microspheres to determine perfusion. Circumflex coronary artery ligation produced acute aneurysmal bulging during isovolumetric contraction and diminished ischemic w...